STERIC MAPPING OF RECEPTOR SITE:STERIC DIFFERENCE METHOD AND APPLICATIONS

作     者：I.MOTOC I.MUSCUTARIU D.CIUBOTARIU 

作者机构：Chemistry Research CenterM.Viteazul 241990 Timisoara 5RomaniaDepartment of Physicsthe University1990 TimisoaraRomaniaDepartment of Organic Chemistrythe Polytechnic1990 TimisoaraRomania 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：1981年第26卷第4期

页      面：361-367页

学科分类：07[理学] 0703[理学-化学] 

主　　题：steric restricted effector bioactive QSAR analogous assumptions abbreviated 吕忱 steps 

摘      要：The current methods available to map the receptor site make use of E_s-type steric constant (for a review, see Ref. [1]). This approach of the steric effects in the effector—biological receptor interactions is restricted to the congeners series of bioactive molecules. The present paper describes a new approach of this problem, namely