THE EFFECT OF RADIATION DOSE RATE ON THE FREQUENCY OF CHROMOSOME ABERRATIONS INDUCED IN HUMAN LEUCOCYTES IRRADIATED IN VITRO

作     者：汪安琦 周宪庭 WONG AN-CHI CHOU SHING-TING Institute of Genetics, Academia Sinica

作者机构：Institute of Genetics Academia Sinica 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：1966年第24卷第3期

页      面：136-137页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：chromosome chromosomal genetics aberration RATE longer break rearrangement contrary minute 

摘      要：The dose rate effect of radiation genetics has been studied intensively because of its practical as well as theoretical importance. According to the classical theory of radiation genetics, the dose-response curve for one-hit chromosome aberrations is linear and independent of the intensity or dose rate of radiation. In the case of two-hit aberrations, the frequency of aberrations increases as the square of the dose. Newcombe postulated that a break in a chromosome may restitute in a given period of time. The phenomena of chromosomal restitution or of the existence of a rejoining system were further confirmed by Wolff et al. If restitution in the first break occurs before the formation of a second break, chromosome aberration of the rearrangement type is no longer possible.