Pharmacogenomics of Cisplatin Sensitivity in Non-small Cell Lung Cancer

作     者：Maimon C.Rose Elina Kostyanovskaya R.Stephanie Huang 

作者机构：Biological Sciences Division University of Chicago Department of Medicine University of Chicago 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2014年第12卷第5期

页      面：198-209页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0714[理学-统计学（可授理学、经济学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 0701[理学-数学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

基　　金：RSH receives support from the NIH/NIGMS (Grant Nos. U01GM61393 and K08GM089941) NIH/NCI (Grant No. R21 CA139278) University of Chicago Cancer Center Support Grant (Grant No. P30 CA14599) Breast Cancer SPORE Career Development Award (Grant No. CA125183) the National Center for Advancing Translational Sciences of the NIH (Grant No. UL1RR024999) of the United States 

主　　题：Cisplatin Non-small cell lung cancer Biomarker Nucleotide excision repair Copper transport Glutathione S-transferase 

摘      要：Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30 years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer （NSCLC） as the standard of care. However, therapeutic outcomes vary from patient to patient. Considerable efforts have been invested to identify biomark- ers that can be used to predict cisplatin sensitivity in NSCLC. Here we reviewed current evidence for cisplatin sensitivity biomarkers in NSCLC. We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways. Current evidence suggests that cisplatin-based treatment could be improved by the use of these biomarkers.