Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence
Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence作者机构:Faculty of ChemistryMazandaran University Department of PathobiologyFaculty of Veterinary MedicineFerdowsi University of Mashhad Veterinary Biotechnology Research GroupInstitute of BiotechnologyFerdowsi University of Mashhad Department of BiochemistryFaculty of Biological SciencesTarbiat Modares University
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2014年第25卷第4期
页 面:630-634页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学]
基 金:the bureau(area)forresearch and technology of Ferdowsi University of Mashhad and Mazandaran University Babolsar Iran
主 题:Chemiluminescence Deferoxamine Free radicals Photon production Stern Volmer plot
摘 要:Removing excessive free radicals (FRs) by a synthetic chemical might give a clue for treatment of many iron-mediated diseases. Deferoxamine (DFO) can be one of the chemicals of choice for the clue. To investigate photoredox properties of DFO, its quenching effect on superoxide radical (O2°), hydrogen peroxide (H202) and hydroxyl radical (OH~) was examined using luminol and ortho-phenanthroline (o- phen) chemiluminescence (CL) systems and UV-vis spectrophotometry. Stern-Volmer equation was also used for the CL kinetics. The observed quenching effect of DFO on CL]photon production in luminol and o-phen CL systems strongly confirmed the static arm of quenching properties of DFO on OH° and H2O2, but much less pronounced on O2^-°; the quenching property was maximal when iron was involved in the reaction systems. The Stern-Volmer plots in the designed photochemical reaction systems also confirmed a potent quenching effect of DFO on FR-mediated CL. Our study highlights strong photoreducing and antioxidant properties of DFO with huge quenching capacity on excessive FRs, and thus implies its promising prospects for therapeutic applications.