13C-methacetin breath test An analysis of some pharmacokinetic parameters obtained from normal adults and patients with hepatic malfunction

作     者：Xia Zonggin Dai Tengchang Hu Yaer (Shanghai Second Medical College)Zhang Naili Lu Yijiang Li Jing (Shanghai Institute of Test Technology)Tang Zhenduo Qiu Yiyong(Ruijin Hospital, Shanghai Second Medical College) 

出 版 物：《核技术》 (Nuclear Techniques)

年 卷 期：1985年第3期

页      面：1-4页

学科分类：08[工学] 0827[工学-核科学与技术] 

主　　题：C methacetin breath test An analysis of some pharmacokinetic parameters obtained from normal adults and patients with hepatic malfunction 

摘      要：Ⅰ . IntroductionCO2-breath tests with 14C or 13C labeled compounds have been shown to be useful or potentially useful in the diagnosis of several importam diseases. Based on the fact that the hepatic microsomal mixed function oxidase can metabolize many drugs through N- or O-demethylation, aminopyrine labeled with 14C or 13C at the N-methyl position have been applied to patients with liver diseases, and a slow down of demethylation as indicated by the decrease of labeled CO2 in exhaled air has been shown to occur in patients with liver *** the aminopyrine breath test suffers from the possibility, though infrequent, of