Toxicity Evaluation of Freshwater Cyanobacterium Microcystis aeruginosa PCC 7806: Ⅱ Nephrotoxicity in Rats

作     者：R. BHATTACHARYA K. SUGENDRAN R. S. DANGI AND P. V. LAKSHMANA RAO (Division of Pharmacology and Toxicology, Division of Synthetic Chem istry, Defence Research and Development Establishment, Jhansi Road, Gwalior 002, India) (Address correspondence t 

作者机构：Division of Pharmacology and Toxicology Defence Research and Development Establishment Gwalior India. 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1997年第10卷第1期

页      面：93-101页

核心收录：

学科分类：100405[医学-卫生毒理学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：PCC Nephrotoxicity in Rats Toxicity Evaluation of Freshwater Cyanobacterium Microcystis aeruginosa PCC 7806 

摘      要：Nephrotoxic potential of laboratory cultures of freshwater cyanobacterium (blue-green al ga) Microcystis aeruginosa PCC 7806 (Pasteur Institute) was assessed in male rats. The ani mals were injected intraperitoneally with 0. 5, 1. 0 and 2. 0 LD50 doses of lyophilized cell ex tract. Elevated plasma urea and creatinine levels were accompanied by decrease in protein and albumin levels, followed by hematuria, proteinuria and bilirubinuria. Also decrease in kidney lactate dehydrogenase and glutamic oxaloacetic transaminase indicated possible nephrotoxic po tential of the cyanobacteria. The extract also produced various hematological changes associat ed with stagnant type of hypoxia. High perfomance liquid chromatography of the culture I dentified the active principle (toxin) as Microcystin-LR