Nutritional assessment in cirrhotic patients with hepatic encephalopathy
作者机构：Gastroenterology DivisionDepartment of Internal Medicine-Botucatu Medical SchoolUNESP-Univ Estadual PaulistaBotucatu 18608-917Sao PauloBrazil
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第30期
页 面：2940-2954页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Sao Paulo Research Foundation(FAPESP) CAPES and PROPe/UNESP Nos.2013/15121-8 and 2013/11761-2
主 题：Hepatic encephalopathy Liver cirrhosis Malnutrition Anthropometry Muscle strength Electric impedance Nutrition assessment Dual-energy X-ray absorptiometry
摘 要：Hepatic encephalopathy(HE) is one of the worst complications of liver disease and can be greatly influenced by nutritional status. Ammonia metabolism, inflammation and muscle wasting are relevant processes in HE pathophysiology. Malnutrition worsens the prognosis in HE, requiring early assessment of nutritional status of these patients. Body composition changes induced by liver disease and limitations superimposed by HE hamper the proper accomplishment of exams in this population, but evidence is growing that assessment of muscle mass and muscle function is mandatory due to the role of skeletal muscles in ammonia metabolism. In this review, we present the pathophysiological aspects involved in HE to support further discussion about advantages and drawbacks of some methods for evaluating the nutritional status of cirrhotic patients with HE, focusing on body composition.
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