Racial/ethnic disparities in hepatocellular carcinoma treatment and survival in California, 1988-2012

作     者：Susan L Stewart Sandy L Kwong Christopher L Bowlus Tung T Nguyen Annette E Maxwell Roshan Bastani Eric W Chak Moon S Chen Jr 

作者机构：Division of BiostatisticsDepartment of Public Health SciencesUniversity of CaliforniaDavis School of Medicine Sacramenio CA 95817 United States California Department of Public Health Sacramenio CA 95817 United States Tung Division of Gastroenterology and HepatologyDepartment of Internal MedicineUniversity of CaliforniaDavis School of Medicine Sacramenio CA 95817 United States Division of General Internal MedicineUniversity of California San Francisco CA 94101 United States UCLA Kaiser Permanente Center for Health EquityFielding School of Public Health and Jonsson Comprehensive Cancer CenterUniversity of California Los Angeles CA 90095 United States Division of Hematology and OncologyDepartment of Internal MedicineUniversity of CaliforniaDavis School of MedicineSacramento CA 95817 United States Cancer Control/Cancer Health DisparitiesUniversity of CaliforniaDavis Comprehensive Cancer CenterSacramento CA 95817 United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第38期

页      面：8584-8595页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Cancer Institute  NCI  (P30CA093373) 

主　　题：Disparities Treatment Survival Liver cancer Hepatocellular carcinoma 

摘      要：AIM To describe racial/ethnic differences in treatment and survival among liver cancer patients in a populationbased cancer *** Invasive cases of primary hepatocellular carcinoma, n = 33270, diagnosed between January 1, 1988-December 31, 2012 and reported to the California Cancer Registry were analyzed by race/ethnicity, age, gender, geographical region, socio-economic status, time period of diagnosis, stage, surgical treatment, and survival. Patients were classified into 15 racial/ethnic groups: non-Hispanic White(White, n = 12710), Hispanic(n = 8500), Chinese(n = 2723), non-Hispanic Black(Black, n = 2609), Vietnamese(n = 2063), Filipino(n = 1479), Korean(n = 1099), Japanese(n = 658), American Indian/Alaskan Native(AIAN, n = 281), Laotian/Hmong (n = 244), Cambodian(n = 233), South Asian(n = 190), Hawai`ian/Pacific Islander(n = 172), Thai(n = 95), and Other Asian(n = 214). The main outcome measures were receipt of surgical treatment, and cause-specific and all-cause *** After adjustment for socio-demographic characteristics, time period, and stage of disease, compared to Whites, Laotian/Hmong [odds ratio(OR) = 0.30, 95%CI: 0.17-0.53], Cambodian(OR = 0.65, 95%CI: 0.45-0.96), AIAN(OR = 0.66, 95%CI: 0.46-0.93), Black(OR = 0.76, 95%CI: 0.67-0.86), and Hispanic(OR = 0.78, 95%CI: 0.72-0.84) patients were less likely, whereas Chinese(OR = 1.58, 95%CI: 1.42-1.77), Koreans(OR = 1.45, 95%CI: 1.24-1.70), Japanese(OR = 1.41, 95%CI: 1.15-1.72), and Vietnamese(OR = 1.26, 95%CI: 1.12-1.42) were more likely to receive surgical treatment. After adjustment for the same covariates and treatment, cause-specific mortality was higher for Laotian/Hmong [(hazard ratio(HR) = 1.50, 95%CI: 1.29-1.73)], Cambodians(HR = 1.35, 95%CI: 1.16-1.58), and Blacks(HR = 1.07, 95%CI: 1.01-1.13), and lower for Chinese(HR = 0.82, 95%CI: 0.77-0.86), Filipinos(HR = 0.84, 95%CI: 0.78-0.90), Vietnamese(HR = 0.85, 95%CI: 0.80-0.90), Koreans(HR = 0.90, 95%CI: 0.83-0.97), and Hispanics(H