Aircraft noise exposure affects rat behavior,plasma norepinephrine levels,and cell morphology of the temporal lobe

作     者：Guo-qing DI Bing ZHOU Zheng-guang LI Qi-li LIN 

作者机构：Institute for Environmental Pollution Control Technology Zhejiang University Hangzhou 310058 China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2011年第12卷第12期

页      面：969-975页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

基　　金：Project supported by the National Natural Science Foundation of China (No. 1060408) the National Public Benefit Research Foundation of China (No. 200809142) 

主　　题：Aircraft noise Open field test Norepinephrine Neuron Synapse 

摘      要：In order to investigate the physiological effects of airport noise exposure on organisms,in this study,we exposed Sprague-Dawley rats in soundproof chambers to previously recorded aircraft-related noise for 65 *** comparison,we also used unexposed control *** was arranged according to aircraft flight schedules and was adjusted to its weighted equivalent continuous perceived noise levels(LWECPN) of 75 and 80 dB for the two experimental *** examined rat behaviors through an open field test and measured the concentrations of plasma norepinephrine(NE) by high performance liquid chromatography-fluorimetric detection(HPLC-FLD).We also examined the morphologies of neurons and synapses in the temporal lobe by transmission electron microscopy(TEM).Our results showed that rats exposed to airport noise of 80 dB had significantly lower line crossing number(P0.05) and significantly longer center area duration(P0.05) than control *** 29 d of airport noise exposure,the concentration of plasma NE of exposed rats was significantly higher than that of the control group(P0.05).We also determined that the neuron and synapsis of the temporal lobe of rats showed signs of damage after aircraft noise of 80 dB exposure for 65 *** conclusion,exposing rats to long-term aircraft noise affects their behaviors,plasma NE levels,and cell morphology of the temporal lobe.