Convenient synthesis of chiral H_4-BINOL via direct hydrogenation of BINOL

作     者：Qian Chang Ding Yun Feng Du Xin Sheng Li Dong Cheng Xu 

作者机构：Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces Institute of Physical Chemistry Zhejiang Normal University Jinhua 321004 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2010年第21卷第11期

页      面：1277-1280页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Science and Technology Department of Zhejiang Province(no.2008C21041) was partially supported by the NSFC(no.20572101) 

主　　题：Hydrogenation 1 1'-Bi-2-naphthol 5 6 7 8-Tetrahydro-1 1'-bi-2-naphthol Chiral Pd/C 

摘      要：A simple,highly effective hydrogenation of chiral BINOL to provide H_4-BINOL in multigram scale with good yield（up to 78% yield） was developed.A series of heterogeneous catalysts was tested in the hydrogenation;;the best result was obtained with 5%Pd/ C in EtOH under the H_2 pressure of 50 bar for 2 *** method is a more useful method for practical synthesis of optically pure H4- BINOL than other available methods.