Risk of contrast-induced nephropathy in hospitalized patients with cirrhosis

作     者：Nilesh Lodhia Michael Kader Thalia Mayes Parvez Mantry Benedict Maliakkal 

作者机构：Department of MedicineDivision of Gastroenterology and HepatologyUniversity of Rochester School of Medicine and DentistryBox 646 601Elmwood AvenueRochesterNY 14642United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第12期

页      面：1459-1464页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Ascites Cirrhosis Contrast-inducednephropathy Renal failure 

摘      要：AIM:To evaluate the incidence of contrast-induced nephropathy(CIN)in cirrhotic patients and to identify risk factors for the development of ***:We performed a retrospective review of 216 consecutive patients with cirrhosis who underwent computed tomography(CT)with intravenous contrast at the University of Rochester between the years *** retrospectively examined factors associated with a high risk for CIN,defined as a decrease in creatinine clearance of 25%or greater within one week after receiving ***:Twenty-five percent of our patients developed CIN,and 74%of these patients had ascites seen on *** the 75%of patients who did not develop CIN,only 46%had *** presence of ascites was a significant risk factor for the development of CIN(P=0.0009,OR 3.38,95%CI 1.55-7.34)in multivariate *** age,serum sodium,Model for End-stage Liver Disease score,diuretic use,and the presence of diabetes were not found to be significant risk factors for the development of *** the patients who developed CIN,11%developed chronic renal insufficiency,defined as a creatinine clearance less than baseline for 6 ***:Our results suggest that in hospitalized cirrhotic patients,especially those with ascites,the risk of CIN is substantial.