Systems understanding of plant-pathogen interactions through genome-wide protein-protein interaction networks

作     者：Hong LI Ziding ZHANG 

作者机构：State Key Laboratory of AgrobiotechnologyCollege of Biological SciencesChina Agricultural University 

出 版 物：《Frontiers of Agricultural Science and Engineering》 (农业科学与工程前沿（英文版）)

年 卷 期：2016年第3卷第2期

页      面：102-112页

学科分类：09[农学] 0904[农学-植物保护] 090401[农学-植物病理学] 

基　　金：supported by grants from the National Natural Science Foundation of China(31271414 31471249) 

主　　题：plant–pathogen interactions systems biology omics plant immunity protein–protein interaction network 

摘      要：Plants are frequently affected by pathogen *** effectively defend against such infections,two major modes of innate immunity have evolved in plants;pathogen-associated molecular pattern-triggered immunity and effector-triggered *** the molecular components as well as the corresponding pathways involved in these two processes have been identified,many aspects of the molecular mechanisms of the plant immune system remain ***,the rapid development of omics techniques(e.g.,genomics,proteomics and transcriptomics) has provided a great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein interactions(PPIs) between plants and pathogens have been carried out and characterized at the network *** this review,we introduce experimental and computational identification methods of PPIs,popular PPI network analysis approaches,and existing bioinformatics resources/tools related to ***,we focus on reviewing the progress in genome-wide PPI networks related to plant–pathogen interactions,including pathogen-centric PPI networks,plant-centric PPI networks and interspecies PPI networks between plants and *** anticipate genome-wide PPI network analysis will provide a clearer understanding of plant–pathogen interactions and will offer some new opportunities for crop protection and improvement.