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Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

作     者:Jiao Wang Ying Zhong Lu Liu Xin Quan Ji Zhi Guo Zhang 

作者机构:Institute of Materia MedicaShandong Academy of Medical SciencesJinan 250062China The National Center for Drug ScreeningShanghai 201203China Pharmacological Institute of New DrugsSchool of PharmacyShandong UniversityJinan 250012China 

出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期:2008年第19卷第4期

页      面:387-389页

核心收录:

学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基  金:National Center for Drug Screening 

主  题:Irisolidone Mannich reaction Mannich base Nitric oxide(NO)production inhibition 

摘      要:Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide(NO)production inhibitory activity was *** 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.

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