Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone
Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone作者机构:Institute of Materia MedicaShandong Academy of Medical SciencesJinan 250062China The National Center for Drug ScreeningShanghai 201203China Pharmacological Institute of New DrugsSchool of PharmacyShandong UniversityJinan 250012China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2008年第19卷第4期
页 面:387-389页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:National Center for Drug Screening
主 题:Irisolidone Mannich reaction Mannich base Nitric oxide(NO)production inhibition
摘 要:Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide(NO)production inhibitory activity was *** 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.