Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

作     者：Jiao Wang Ying Zhong Lu Liu Xin Quan Ji Zhi Guo Zhang 

作者机构：Institute of Materia MedicaShandong Academy of Medical SciencesJinan 250062China The National Center for Drug ScreeningShanghai 201203China Pharmacological Institute of New DrugsSchool of PharmacyShandong UniversityJinan 250012China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第4期

页      面：387-389页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：National Center for Drug Screening 

主　　题：Irisolidone Mannich reaction Mannich base Nitric oxide(NO)production inhibition 

摘      要：Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide（NO）production inhibitory activity was *** 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.