Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis
Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis作者机构：Department of Faculty Surgery South Ural State Medical University Department of Hospital SurgerySouth Ural State Medical University
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2016年第8卷第16期
页 面：665-672页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Liver cirrhosis Endothelial dysfunction Sinusoidal remodeling Intrahepatic angiogenesis Pathogenesis of portal hypertension
摘 要：Pub Med, EMBASE, Orphanet, MIDLINE, Google Scholar and Cochrane Library were searched for articles published between 1983 and 2015. Relevant articles were selected by using the following terms: Liver cirrhosis, Endothelial dysfunction, Sinusoidal remodeling, Intrahepatic angiogenesis and Pathogenesis of portal hypertension. Then the reference lists of identified articles were searched for other relevant publications as well. Besides gross hepatic structural disorders related to diffuse fibrosis and formation of regenerative nodules, the complex morphofunctional rearrangement of the hepatic microvascular bed and intrahepatic angiogenesis also play important roles in hemodynamic disturbances in liver cirrhosis. It is characterized by endothelial dysfunction and impaired paracrine interaction between activated stellate hepatocytes and sinusoidal endotheliocytes, sinusoidal remodeling and capillarization, as well as development of the collateral microcirculation. In spite of the fact that complex morphofunctional rearrangement of the hepatic microvascular bed and intrahepatic angiogenesis in liver cirrhosis are the compensatory-adaptive reaction to the deteriorating conditions of blood circulation, they contribute to progression of disease and development of serious complications, in particular, related to portal *** Med,EMBASE,Orphanet,MIDLINE,Google Scholar and Cochrane Library were searched for articles published between 1983 and *** articles were selected by using the following terms:Liver cirrhosis,Endothelial dysfunction,Sinusoidal remodeling,Intrahepatic angiogenesisandPathogenesis of portal hypertension.Then the reference lists of identified articles were searched for other relevant publications as *** gross hepatic structural disorders related to diffuse fibrosis and formation of regenerative nodules,the complex morphofunctional rearrangement of the hepatic microvascular bed and intrahepatic angiogenesis also
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