Occult hepatitis B virus infection and cryptogenic chronic hepatitis in an area with intermediate prevalence of HBV infection

作     者：Mohammad Javad Kaviani Behzad Behbahani Mohammad Jafar Mosallaii Fatemeh Sari-Aslani Seyed Alireza Taghavi 

作者机构：Gastroenterohepatology research centerDepartment of Internal medicineNamazee HospitalShiraz University of medical sciencesShirazIran Professor Abdolvahhab Alborzi's pediatric clinical microbiology research centerNamazee HospitalShiraz University of medical sciencesShirazIran Department of pathologyShiraz University of medical sciencesShirazIran 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第31期

页      面：5048-5050页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Hepatitis B Cryptogenic chronic hepatitis PCR 

摘      要：AIM： To assess the possible role of occult HBV infection in the pathogenesis of chronic hepatitis in Iranian patients. METHODS： After exclusion of autoimmune, metabolic and viral etiologies, 104 consecutive adult patients with histologic and biochemical features of chronic hepatitis and negative HBsAg were enrolled in the study. Qualitative PCR with a sensitivity of 150 × 10^3 copies/L, using two primers for Pre-S and core regions was applied to measure presence of HBV DNA in serum of the patients. RESULTS： All 104 patients completed the study Qualitative HBV DNA was positive in two patients （1.9%） CONCLUSION： Occult HBV infection has negligible role in the pathogenesis of cryptogenic chronic hepatitis in Iranian patients.