囊性纤维化患者宫颈内膜化生报道1例

作     者：Piccoli R Di Spiezio Sardo A Insabato L 张旸(译) 景永哲(校) 

作者机构：不详 University of Naples Federico Ⅱ Department of Gynecology and Obstetrics Pathophysiology of Human Reproduction Via Pansini 5 Naples Italy 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第6期

页      面：39-39页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：囊性纤维化 宫颈内膜 化生 患者 孕激素制剂 宫腔镜诊断 组织学检查 随机活检 宫腔镜 不孕妇女 

摘      要：Objective: To report the case of an infertile female patient with cystic fibrosis who was diagnosed with endocervical metaplasia of the endometrium at diagnostic hysteroscopy and successfully treated with an oral estroprogestinic formulation. Design: Case report. Setting: University hospital. Patient(s): A 27- year- old infertile female patient with cystic fibrosis. Intervention(s): Hysteroscopy with multiple random biopsies was performed at the time of the first visit and after a 10- month cycle with an oral estroprogestinic formulation. Main Outcome Measure(s): Hysteroscopic evaluation with target biopsy; histological examinations of endometrial specimens. Result(s): Our patient benefited from a 10- month cycle with an oral estroprogestinic formulation. At the control visit we noticed a significant improvement in the hysteroscopic appearance of her endometrium, and the histological examination confirmed the complete reversion of the metaplastic alterations previously observed. Conclusion(s): The present report suggests a novel histological alteration possibly involved in affecting fertility in women with cystic fibrosis. In addition, the positive response to the estroprogestinic treatment observed in our patient poses new questions regarding the relationship between ovarian hormones and cystic fibrosis transmembrane conductance regulator protein regulation, offering interesting perspectives for a hormonal therapy in the treatment of subfertility in women with cystic fibrosis.