Oncogenic Wnt3a expression as an estimable prognostic marker for hepatocellular carcinoma
Oncogenic Wnt3a expression as an estimable prognostic marker for hepatocellular carcinoma作者机构：Research Center of Clinical Medicine Affiliated Hospital of Nantong University Departments of Immunology Medical College of Nantong University Department of Oncology Affiliated Hospital of Nantong University Medical Informatics Medical College of Nantong University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2016年第22卷第14期
页 面：3829-3836页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the International S&T Cooperation Program No.2013DFA32150 of China
主 题：Hepatocellular carcinoma Prognosis Wnt3a Wnt/β -catenin signal Tissue microarrays Immunohistochemistry
摘 要：AIM: To investigate member 3a of Wingless-type MMTV integration site family (Wnt3a) expression in cancerous and surrounding tissues and the relationship between clinicopathologic features of hepatocellular carcinoma (HCC) and Wnt3a ***: Wnt3a expression and cellular distribution and clinicopathologic characteristics in cancerous tissue and matched surrounding tissues were analyzed in 80 HCC patients from January 2006 to August 2008 by tissue microarrays and immunohistochemistry. The overall and disease-free survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions ***: The incidence of oncogenic Wnt3a expression in the cancerous group was up to 96.25% (77 of 80), which was significantly higher (χ2 = 48.818, P 2 = 20.211, P 2 = 8.467, P 2 = 12.957, P 2 = 22.960, P 2 = 15.469, P 0.001).CONCLUSION: Oncogenic Wnt3a expression associated with HBV infection and cirrhotic liver might be an independent prognostic factor for HCC.
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