Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism
Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism作者机构：Guangxi Medical University Hainan Medical University the Affiliate Hospital of Hainan Medical College
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2016年第9卷第7期
页 面：688-692页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Viral hepatitis type B Cirrhosis Hypersplenism Partial splenic embolization Immune function
摘 要：Objective:To discover the effect of partial splenic embolization on the immune function of cirrhotic patients with ***:Patients involved in the study were enrolled and divided into three groups,including control group,experimental group,and complication *** of CD3^+,CD4^+ and CD8^+ T cells and CD4^+CD25^+CDl27^(low/-) Treg cells in the peripheral blood of patients before surgery,1 month,6 months,1 year,and 2 years after surgery were analyzed by fluorescence active cell sorting(FACS).Contents of immunoglobulins(IgA,IgG and IgM) were analyzed by auto immunoassay ***:In the peripheral blood of patients from experimental group,numbers of CD3^+,CD4^+ and CD8^+ T cells initially declined,but afterwards increased to normal level;in the peripheral blood of patients from complication group,CD3^+ and CD8^+ T cells showed the same trend,but the number of CD4^+ T cells was below normal level at all detection ***,CD3^+,CD4^+ and CD8^+ T cells in the peripheral blood of patients from complication group were initially less than those in experimental group,and afterwards were comparable between two *** patients from both experimental group and complication group,the number of CD4^+CD25^+CDl27^(low/-)Treg cells increased 1 month and 6 months after surgery,and gradually restored to normal ***4^+CD25^+CDl27^(low/-)Treg cell counts in patients from complication group were initially more than those in patients from experimental group 1 month and 6 months after surgery,but then they were ***,contents of immunoglobulins(IgA,IgG and IgM) were comparable in three groups at all detection ***:Partial splenic embolization influenced the immune function of cirrhotic patients with hypersplenism in the short term but the immune function could afterwards gradually restore to *** results implicated that measures that prevent infection and improve immune function were necessary in early stage aft
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