Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome

作     者：Farhad Sahebjam Cristina H Hajdu Esther Nortey Samuel H Sigal 

作者机构：Division of Gastroenterology New York University School of Medicine Department of Pathology New York University School of Medicine Division of Gastroenterology and Liver Diseases Montefiore Medical Center and Albert Einstein College of Medicine 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2016年第8卷第14期

页      面：632-636页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：AbbVie Gilead 

主　　题：Hepatitis C Autoimmune hepatitis Overlap syndrome Direct acting antiviral therapy 

摘      要：Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.