Possible role of PGD_2 in malaria infections
Possible role of PGD_2 in malaria infections作者机构：Graduate Program in Bioclinical SciencesChulabhorn International College of MedicineThammasat University Graduate Program in Biomedical SciencesFaculty of Allied Health SciencesThammasat University Department of HematologyRama College of MedicineMahidol University Center of Excellence in Pharmacology and Molecular Biology of Malaria and CholangiocarcinomaThammasat University
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2016年第9卷第9期
页 面：834-837页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Malaria Plasmodium vivax Plasmodium falciparum Prostaglandin D2(PGD2) Malaria severity
摘 要：Objective:To preliminarily investigate the possible role of prostaglandin D_2(PGD_2) in malaria ***:Blood and urinary samples(n=120 each) were collected from Thai patients with Plasmodium falciparum(***) with moderate(n=26) and high(n=4) parasitemia,patients with Plasmodium vivax(***)(n=30),patients with fever associated with other infections(n=30),and healthy subjects(n=30).PGD_2 concentrations in plasma and urinary samples of healthy subjects,patients with fever associated with other infections and patients with malaria were determined using Prostaglandin D2-MOX express EIA kit(Cayman Chemical,USA).Results:The possible association between PGD_2 and malaria infections is clearly demonstrated with PGD_2 concentration in *** urinary PGD_2 concentrations were relatively high(about 5-fold) in patients with *** with moderate parasitemia and *** infections compared with other ***,the concentration in patients with *** with moderate parasitemia and *** infection were significantly higher than that in healthy subjects and patients with fever associated with other ***:Urinary PGD_2 concentrations may offer a more dependable and useful tool for predicting malaria *** is this preliminary finding is required with a larger sample size.
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