Cardiovascular drugs in the treatment of infantile hemangioma
Cardiovascular drugs in the treatment of infantile hemangioma作者机构：Department of Surgery St. Jude Children’s Research Hospital Department of Pediatric Surgery Le Bonheur Children’s Hospital Department of Pediatric Cardiology Le Bonheur Children’s Hospital
出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)
年 卷 期：2016年第8卷第1期
页 面：74-80页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Infantile hemangioma beta-blockers Renin-angiotensin system Angiogenesis
摘 要：Since the introduction of propranolol in the treatment of complicated infantile hemangiomas(IH) in 2008, other different beta-blockers, including timolol, acetabutolol, nadolol and atenolol, have been successfully used for the same purpose. Various hypotheses including vasoconstriction, inhibition of angiogenesis and the induction of apoptosis in proliferating endothelial cells have been advanced as the potential beta-blockerinduced effect on the accelerated IH involution, although the exact mechanism of action of beta-blockers remains unknown. This has generated an extraordinary interest in IH research and has led to the discovery of the role of the renin-angiotensin system(RAS) in the biology of IH, providing a plausible explanation for the beta-blocker induced effect on IH involution and the development of new potential indications for RAS drugs such as angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in the treatment of IH. This review is focused on the current use of cardiovascular drugs in the treatment of IH.
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