Neuroimaging the brain-gut axis in patients with irritable bowel syndrome
Neuroimaging the brain-gut axis in patients with irritable bowel syndrome作者机构：Digestive Disorders Unit Biobehavioral Branch Division of Intramural Research National Institute of Nursing Research National Institutes of Health Department of Health and Human Services College of Nursing New York University Division of Intramural Research National Institute of Nursing Research National Institutes of Health Department of Health and Human Services
出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)
年 卷 期：2016年第7卷第2期
页 面：320-333页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Division of Intramural Research National Institute of Nursing Research to W.A.H No.1ZIANR000018-01-05
主 题：Irritable bowel syndrome Neuroimaging Brain-gut axis Functional magnetic resonance imaging
摘 要：AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February *** filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human *** initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study *** were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate ***:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient *** in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con ***:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population.
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