Comparison of intravenous pantoprazole and ranitidine in patients with dyspepsia presented to the emergency department: a randomized, double blind, controlled trial

作     者：Engin Senay Cenker Eken Murat Yildiz Derya Yilmaz Erhan Alkan Mete Akin Mustafa Serinken 

作者机构：Department of Emergency Medicine School of Medicine Akdeniz University Department of Gastroenterology School of Medicine Akdeniz University Department of Gastroenterology Burdur Government Hospital Pamukkale University Hospital Department of Emergency Medicine 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2016年第7卷第1期

页      面：30-34页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Akdeniz University Foundation 

主　　题：Dyspepsia Pantoprazole Ranitidine Emergency department 

摘      要：BACKGROUND:This study aimed to compare pantoprazole,a proton-pomp inhibitors(PPIs),and ranitidine,a H2 receptor antagonists(H2RA),in ceasing dyspeptic symptoms in the emergency department(ED).METHODS:This randomized,double-blinded study compared the effectiveness of 50 mg ranitidine(Ulcuran®)and 40 mg pantoprazole(Pantpas®),given in a 100 m L saline solution by an intravenous rapid infusion within 2–4 minutes in patients with dyspepsia presented to the *** intensity was measured at baseline,30 and 60 minutes after the drug ***:A total of 72 patients were eligible for the *** these patients,2 were excluded from the study because the initial visual analogue scale(VAS)scores were under 20 mm and 4 were excluded from the statistical analysis because of being diagnosed as having other causes of epigastric pain despite being allocated to one of the study ***-three patients in the pantoprazole group and 33 patients in the ranitidine group were analyzed *** mean age of the patients was36.6±15 years,and 26(39.4%)patients were *** of the groups reduced pain effectively at 30[27.6±28(18 to 37)vs.28.3±23(20 to 37),respectively]and 60 minutes[39.6±39(26 to 53)vs.42.3±25(33 to 51),respectively].There were 13(39.4%)patients in the pantoprazole group and 8(24.2%)patients in the ranitidine group who required additional drug at the end of the study(P=0.186).CONCLUSION:Intravenous pantoprazole and ranitidine are not superior to each other in ceasing dyspeptic symptoms at 30 and 60 minutes in the ED.