Microfluidics: Rapid Diagnosis for Breast Cancer

作     者：Satvinder Panesar Suresh Neethirajan 

作者机构：BioNano Laboratory School of Engineering University of Guelph 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2016年第8卷第3期

页      面：204-220页

核心收录：

学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：the Natural Sciences and Engineering Research Council of Canada the Ontario Ministry of Research and Innovation for funding this study 

主　　题：Mircofluidics Mi RNA Biomarkers Diagnostic technology Breast cancer 

摘      要：Breast cancer affected 1.7 million people worldwide in 2012 and accounts for approximately 23.3 % of all cancers diagnosed in women. The disease is characterized by a genetic mutation, either inherited or resulting from environmental factors, that causes uncontrollable cellular growth of breast tissue or adjacent tissues. Current means of diagnosing this disease depend on the individual analyzing the results from bulky, highly technical, and expensive equipment that is not globally accessible. As a result, patients can go undiagnosed due to a lack of available equipment or be overdiagnosed due to human error. This review attempts to highlight current means of diagnosing breast cancer and critically analyze their effectiveness and usefulness in terms of patient survival. An alternative means based on microfluidics biomarker detection is then presented. This method can be considered as a primary screening tool for diagnosing breast cancer based on its robustness, high throughput, low energy requirements, and accessibility to the general public.