A nucleophilic 1,3-rearrangement leading to 3,4-disubstituted 3,4-dihydroquinolines

作     者：Chun-Xian He Zhi-Bo Jiang Hua-Qing Cui Da-Li Yin 无

作者机构：State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Department of Medicinal Chemistry Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第7期

页      面：1036-1039页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：‘‘The National High-Tech Research and Development Program (‘‘863’’Program) of China’’No. 2012AA020302) for financial support 

主　　题：1,3-Rearrangement Dihydroquinoline derivatives Reaction mechanism 

摘      要：A new nucleophilic 1,3-rearrangement is observed when treating 2-methoxyquinolino-3-lithium with an α-C substituted deoxybenzoin,and this rearrangement yielded an unusual 3,4-disubstituted 3,*** similar reactions were designed and executed to investigate this novel 1,3-rearrangement,and a mechanism involving a nucleophilic addition and a following 1,3-rearrangement with an unusual dearomatization on the quinoline ring is proposed.