Elastin-like polypeptide fusion for precision design of protein-polymer conjugates with improved pharmacology

作     者：Youqing Shen 

作者机构：Center for Bionanoengineering & Key Laboratory of Biomass Chemical Engineering of Ministry of Education Department of Chemical and Biological EngineeringZhejiang University 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2015年第58卷第10期

页      面：767-768页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

主　　题：IFN Elastin-like polypeptide fusion for precision design of protein-polymer conjugates with improved pharmacology 

摘      要：Therapeutic proteins and peptides are characteristic by their high biological activity and specificity,but their clinical uses are bottlenecked by their poor stability,short in vivo half-life and immunogenicity[1].One typical example is recombinant human interferon alpha(IFN-α),FDA-approved and widely used in treatments of viral diseases and cancer,yet its short plasma half-life(t1/2=2-4 h)necessi-