Molecular Tissue Engineering:Concepts,Status and Challenge

作     者：郭晓东 GUO Xiao dong 1) ZHENG Qi xin 1) DU Jing yuan 1) YANG Shu hua 1) WANG Hong 1) SHAO Zeng wu 1) SUN En jie 2) 1) Tongji Medical College,Huazhong University of Science and Technology 2) Wuhan

作者机构：TongjiMedicalCollegeHuazhongUniversityofScienceandTechnology 

出 版 物：《Journal of Wuhan University of Technology(Materials Science)》 (武汉理工大学学报（材料科学英文版）)

年 卷 期：2002年第17卷第3期

页      面：30-34页

核心收录：

学科分类：08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：ThisprojectwassupportedbytheNationalNaturalScienceFoundationofChina(30 170 2 70 ) 

主　　题：tissue engineering stem cell gene therapy biomimetic biomaterials molecular biology molecular tissue engineering growth factor delivery 

摘      要：Tissue engineering has confronted many difficulties mainly as follows:1)How to modulate the adherence,proliferation,and oriented differentiation of seed cells, especially that of stemcells. 2) Massive preparation and sustained controllable delivery of tissue inducing factors or plasmid DNA, such as growth factors, angiogenesis stimulators,and so on. 3) Development of intelligent biomimetic materials as extracellular matrix with a good superficial and structural compatibility as well as biological activity to stimulate predictable, controllable and desirable responses under defined *** biology is currently one of the most exciting fields of research across life sciences,and the advances in it also bring a bright future for tissue engineering to overcome these *** recent years,tissue engineering benefits a lot from molecular *** a comprehensive understanding of the involved ingredients of tissue engineering (cells,tissue inducing factors,genes,biomaterials) and the subtle relationships between them at molecular level can lead to a successful manipulation of reparative processes and a better biological *** tissue engineering,the offspring of the tissue engineering and molecular biology,has gained an increasing importance in recent *** offers the promise of not simply replacing tissue,but improving the *** studies presented in this article put forward this new concept for the first time and provide an insight into the basic principles,status and challenges of this emerging technology.