VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism
VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism出 版 物：《世界最新医学信息文摘》 (World Latest Medicine Information)
年 卷 期：2016年第4期
页 面：8-8页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
主 题：Vascular biology Cell therapy Stem cell Inflammation
摘 要：Recruitment and retention of circulating progenitor cells at the site of injured or ischemic tissues facilitates adult *** hypothesized that cell therapy could modulate local neo-vascularization through the vascular endothelial growth factor（VEGF）/stromal cellderived factor-1（SDF-1）axis and by paracrine effects on local endothelial *** isolated from rat bone marrow a subset of multipotent adult progenitor cell-derived progenitor cells（MDPC）.In vitro,MDPCs secreted multiple cytokines related to inflammation and angiogenesis,including monocyte chemotactic protein-1,SDF-1,basic fibroblast growth factor,and VEGF,and expressed the chemokine receptors CXCR4 and *** investigate in vivo properties,we transplanted MDPCs into the ischemic hind limbs of *** levels of the chemokine SDF-1 and colocalization of CD11b+cells marked the initial phase of tissue remodeling after cell *** engraftment was observed in the adventitial-medial border region of arterioles of ischemic ***,engrafted cells did not differentiate into endothelial or smooth muscle *** perfusion normalized 4 weeks after cell *** of SDF-1 reduced the engraftment of transplanted cells and decreased endothelial cell *** findings suggest a two-stage model whereby transplanted MDPCs modulate wound repair through recruitment of inflammatory cells to ischemic *** is an important potential mechanism for cell transplantation,in addition to the direct modulation of local vascular cells through paracrine mechanisms.
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