Effect of preoperative injection of carbon nanoparticle suspension on the outcomes of selected patients with mid-low rectal cancer

作     者：Xing-Mao Zhang Jian-Wei Liang Zheng Wang Jian-tao Kou Zhi-Xiang Zhou 

作者机构：Department of Hepatobiliary SurgeryBeijing Chaoyang HospitalCapital Medical University Department of Gastrointestinal SurgeryCancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College 

出 版 物：《Chinese Journal of Cancer》 (Chin. J. Cancer)

年 卷 期：2016年第35卷第5期

页      面：250-254页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Carbon nanoparticle suspension, Rectal cancer 

摘      要：Background:Carbon nanoparticles show significant lymphatic tropism and can be used to identify lymph nodes surrounding mid-low rectal *** this study,we analyzed the effect of trans anal injection of a carbon nanoparticle suspension on the outcomes of patients with mid-low rectal cancer who underwent laparoscopic ***:We collected the data of 87 patients with mid-low rectal cancer who underwent laparoscopic resection between November 2014 and March 2015 at Cancer Hospital,Chinese Academy of Medical Sciences & Peking Union Medical *** 35 patients in the experimental group,the carbon nanoparticle suspension was injected transanally into the submucosa of the rectum around the tumor 30 min before the operation;52 patients in the control group underwent the operation directly without the injection of carbon nanoparticle *** then compared the operation outcomes between the two ***:In the experimental group,the rate of incomplete mesorectal excision was lower than that in the control group,but no significant difference was found(2.9%vs.7.7%,P = 0.342).The distance between the tumor and the circumferential resection margin was 5.8 ± 1.4 mm in the experimental group and 4.8 ±1.1 mm in the control group(P = 0.001).The mean number of lymph nodes removed was 28.2 ± 9.4 in the experimental group and 22.7 ± 7.3in the control group(P = 0.003);the mean number of lymph nodes smaller than 5 mm in diameter was 10.1 ± 7.5and 4.5 ±3.7,respectively(P 0.001).Three patients in the experimental group received lateral lymph node *** the three patients,we retrieved three nodes(one stained node) from the first patient,three nodes(two stained nodes) from the second patient,and two nodes(no stained nodes) from the third ***:Injecting a carbon nanoparticle suspension improved the outcomes of patients who underwent laparoscopic resection for mid-low rectal cancer;it also improved the accuracy of pathologic ***