Virus like particle-based vaccines against emerging infectious disease viruses

作     者：Jinliang Liu Shiyu Dai Manli Wang Zhihong Hu Hualin Wang Fei Deng 

作者机构：State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2016年第31卷第4期

页      面：279-287页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：emerging infectious disease self-assembly vaccine virus virus-like particle(VLP) 

摘      要：Emerging infectious diseases are major threats to human *** severe viral disease outbreaks occur in developing regions where health conditions are *** increased international travel and business,the possibility of eventually transmitting infectious viruses between different countries is *** most effective approach in preventing viral diseases is ***,vaccines are not currently available for numerous viral *** particles(VLPs) are engineered vaccine candidates that have been studied for *** are constructed by viral protein expression in various expression systems that promote the selfassembly of proteins into structures resembling virus *** have antigenicity similar to that of the native virus,but are non-infectious as they lack key viral genetic *** vaccines have attracted considerable research interest because they offer several advantages over traditional *** have shown that VLP vaccines can stimulate both humoral and cellular immune responses,which may offer effective antiviral *** we review recent developments with VLP-based vaccines for several highly virulent emerging or re-emerging infectious *** infectious agents discussed include RNA viruses from different virus families,such as the Arenaviridae,Bunyaviridae,Caliciviridae,Coronaviridae,Filoviridae,Flaviviridae,Orthomyxoviridae,Paramyxoviridae,and Togaviridae families.