Synthesis,Characterization,and DNA Binding Properties of Dinuclear Copper(Ⅱ) Complex [Cu_2(TATP)_2(L-Leu)_2(ClO_4)_2]_2·2H_2O

作     者：GU Qin LIN Qing-bin LIU Ying-ju LE Xue-yi FENG Xiao-long 

作者机构：Department of Applied Chemistry College of Sciences South China Agricultural University Guangzhou 510642 P. R. China Center of Analysis and Measurement Zhongshan University Guangzhou 510275 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2008年第24卷第4期

页      面：401-406页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：the Natural Science Foundation of Guangdong Province China(No. 04105986) 

主　　题：Copper(Ⅱ) complex 1,4,8,9-Tetraazatriphenylene L-Leucinate DNA 

摘      要：A dinuclear copper（Ⅱ） complex[Cu2（TATP）2（L-Leu）2（CIO4）2]2·2H2Owas synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1, with two independent molecules in a unit cell. Two Cu（Ⅱ） ions in each complex [Cu2（TATP）2（L-Leu）2（CIO4）2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.