Total Synthesis of N-Methylsansalvamide A

作     者：Shou Xin LIU Yan Lou GENG Xia TIAN Xiao Li ZHEN Jian Rong HAN 

作者机构：College of chemical ＆ pharmaceutical Engineering Hebei University of Science ＆ Tecnnology Shijiazhuang 050018 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第6期

页      面：761-764页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 100701[医学-药物化学] 

基　　金：The authors are grateful to The National Natural Science Foundation of China (No.30472074) to The Hebei province Natural Science Foundation (No.B2006000302) for financial support of this work 

主　　题：Synthesis N-methylsansalvamide A solution phase cyclic depsipeptide. 

摘      要：Total synthesis of N-methylsansalvamide A was accomplished in solution phase by a convergent approach. An N-Boc-td-depsipepide 6 and a dipeptide ester 10 were prepared in the yield of 89% and 91%, respectively. Cyclization of the linear penta-depsipetide was achieved with PyBOP and DIPEA in DMF-CH2C12.