Separation of chiral drugs with β-CD phosphate by capillary electrophoresis

作     者：Xue Qin REN1 Xiao Dan SU1 Al Jin HUANG1 Yi Liang SUN1 Zeng Pei SUNZ2 (1 Department of Chemistry, Peking University, Beijing 100871 2 National Institute for the Control of pharmaceutical and Biological Products, Beijing 100050) 

作者机构：Department of Chemistry Peking University Beijing 100871 China Natl. Inst. Contr. Pharmaceutical B. Beijing 100050 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2000年第11卷第2期

页      面：153-156页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：Doctoral Program Foundation of National Ministry of Education of China 

主　　题：Capillary electrophoresis chiral separation β-cyclodextrin-phosphate isoprenaline methoxamine oxprenolol practolol. 

摘      要：β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.