Association between telomere length and survival in cancer patients： a meta-analysis and review of literature
Association between telomere length and survival in cancer patients： a meta-analysis and review of literature作者机构：Department of Hepatobiliary Surgery the First Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi 'an 710061 China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2016年第10卷第2期
页 面：191-203页
核心收录：
学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 1002[医学-临床医学] 07[理学] 0905[农学-畜牧学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
主 题：telomere survival cancer meta-analysis
摘 要：The relationship between telomere length and cancer survival has been widely studied. To gain a deeper insight, we reviewed the published studies. A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomere length in the tumor tissue. First, in the peripheral blood studies, for solid tumor patients with shortened telomere length, the combined hazard ratios （HRs） for mortality and tumor progression were 1.21 （95%CI, 1.10-1.32） and 1.71 （95%CI, 1.37-2.13）, respectively. Meanwhile, in hematology malignancy, the combined HRs for mortality and tumor progression were 2.83 （95%CI, 2.14-3.74） and 2.65 （95%CI, 2.18-3.22）, respectively. Second, in the studies that use tumor tissue, for patients with shortened telomeres, the combined HRs for mortality and tumor progression were 1.26 （95%CI, 0.95-1.66） and 1.65 （95%CI, 1.26-2.15）, respectively. In the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, for patients with lower telomere length ratios, the combined HRs were 0.66 （95%CI, 0.53-0.83） and 0.74 （95%CI, 0.41-1.32） for mortality and tumor progression, respectively. In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival for cancer patients. However, by calculating the telomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival.
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