Two new eupodienone lignans from Gymnotheca chinensis

作     者：Shi-Ji Xiao Fang Chen Li-Sheng Ding Yan Zhou 

作者机构：Key Laboratory of Mountain Ecological Restoration and Bioresource UtilizationChengdu Institute of BiologyChinese Academy of Sciences College of Life ScienceSichuan University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第3期

页      面：463-464页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 

基　　金：financially supported by the grant from the National Natural Sciences Foundation of China (No. 30973634) 

主　　题：Gymnotheca chinensisSaururaceaeEupodienoneLignan 

摘      要：Two new eupodienone lignans, named gymnothelignan T （1） and gymnothelignan U （2） were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis （Saururaceae）. The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound I was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.