Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells

作     者：Zhi-gao Sun Li-ping Chen Fa-wei Wang Cheng-yong Xu Miao Geng 

作者机构：Department of Traditional Chinese MedicineHainan Branch Hospital of Chinese PLA General Hospital Department of Traditional Chinese MedicineChinese PLA General Hospital Institute of GerontologyChinese PLA General Hospital 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第7期

页      面：1159-1164页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Research and Development Project Fund of Science and Technology Plan Program of Science and Technology Bureau of Beijing of China No.Z111107067311022 

主　　题：ginsenoside neuroblastoma peroxide injured protective caspase dehydrogenase suppressed manner antioxidant 

摘      要：The active ingredient of ginseng,ginsenosides Rg1,has been shown to scavenge free radicals and improve antioxidant *** study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma cells injured by *** Rg1 at different concentrations（50 and 100 μM） was used to treat H2O2（150 μM）-injured SH-SY5 Y *** demonstrated that ginsenoside Rg1 elevated the survival rate of SH-SY5 Y cells injured by H2O2,diminished the amount of leaked lactate dehydrogenase,and increased superoxide dismutase *** Rg1 effectively suppressed caspase-3 immunoreactivity,and contributed to heat shock protein 70 gene expression,in a dose-dependent *** results indicate that ginsenoside Rg1 has protective effects on SH-SY5 Y cells injured by H2O2 and that its mechanism of action is associated with anti-oxidation and the inhibition of apoptosis.