淋巴管瘤样Kaposi肉瘤

作     者：Ramirez J.A. Laskin W.B. Guitart J. 李政霄 

作者机构：645 North Michigan Avenue Chicago IL 60611 United States 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第9期

页      面：57-58页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Kaposi 淋巴管瘤 免疫组化试验 抗人疱疹病毒 临床亚型 卡波 活检标本 核抗原 皮肤病理 病灶区 

摘      要：Background:Lymphangioma-like Kaposi’s sarcoma (LLKS) is a rare morphologic expression of Kaposi’s sarcoma (KS) that occurs in virtually all of the well-recognized clinical subtypes of the disease and has the potential to mimic other pathologic processes. In this study, we present the clinical and pathological features of four patients with LLKS. Methods:Four cases of LLKSwereretrievedfromthedermatopathologyfilesofourinstitution. All four tumours were tested immunohistochemically with anti-human herpesvirus-8(HHV-8) latent nuclear antigen1 (LNA-1) and anti-CD34 antibodies. Results:Clinically, each patient presented with violaceous patches, papules or plaques; one patient presented with bullous lesions. All of the LLKS biopsy specimens revealed areas with characteristic light microscopic features of KS. Lymphangioma-like foci consisted of ectatic, irregularly shaped vascular spaces lined by mildly atypical endothelial cells. All tumour cells, including those associated with LLKS foci, showed a strong and diffuse reactivity for anti-HHV-8 LNA-1 and anti-CD34. KS progressed slowly in two patients with adequate follow-up. Conclusions:As LLKS can mimic other disease processes, the correct diagnosis relies heavily on the recognition of salient clinical and histological features of conventional KS, including a strong immunohistochemical expression of HHV-8-associated LNA-1 in lesional cells.