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文献详情 >自体表皮细胞悬液移植治疗白癜风的双盲安慰剂对照研究 收藏

自体表皮细胞悬液移植治疗白癜风的双盲安慰剂对照研究

Double-blind placebo-controlled study of autologous transplanted epidermal cell suspensions for repigmenting vitiligo

作     者:Van Geel N. Ongenae K. De Mil M J.M.Naeyaert 罗素菊 冯义国 

作者机构:Department of Dermatology Ghent University Hospital De Pintelaan 185 9000Ghent Belgium Dr. 

出 版 物:《世界核心医学期刊文摘(皮肤病学分册)》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期:2005年第1卷第2期

页      面:7-8页

学科分类:1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主  题:细胞悬液 白斑皮损 安慰剂对照 稳定期 细胞移植物 黑色素细胞 对称分布 医疗机构 图像分析系统 弥漫性 

摘      要:Objectives: To investigate the efficacy of epidermal noncultured cellular grafting in patients with vitiligo and the role of postinflammatory, spontaneous, or UV-induced pigmentation in obtaining repigmentation. Design: A prospective, randomized, double-blind, placebo-controlled study. Setting: Ambulatory patients in an institutional practice. Patients were followed up for 3 to 12 months. Patients: A total of 33 paired, symmetrically distributed leukodermic lesions, all resistant to therapy, were observed in 28 patients. Nineteen patients appeared to have a stable vitiligo (group 1), whereas there was doubt about the stability of the disease in 9 patients (group 2). Intervention: After laser ablation, a hyaluronic acid-enriched cellular graft was applied to 1 lesion while the paired lesion received placebo. Three weeks later all lesions were exposed to UV irradiation twice per week for approximately 2 months. Main Outcome Measures: Primarily, the percentage of repigmentationwas assessed after 3, 6, and 12months using a digital image analysis system. The repigmentation patternwas also evaluated after 1 and 3 months. Results: A strongly significant difference between cellular grafts and placebo was observed after 3, 6, and 12 months (P .001, P=.002, and P=.002, respectively). In group 1, repigmentation of at least 70%of the treated area was achieved in 55%, 57%, and 77%of the actively treated lesions 3, 6, and 12 months after treatment, whereas in group 2 repigmentation of at least 70%of the treated area was not observed at any time point. The repigmentation pattern was diffuse in 94%of the responding patients. Conclusions: After a strict preoperative selection for disease stability, transplantation resulted in repigmentation of at least 70%of the treated area in most actively treated vitiligo lesions. Repigmentation was primarily caused by the transplanted melanocytes.

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