Prenylated flavonoids from Glycyrrhiza uralensis as promising anti-cancer agents: a preliminary structure-activity study
甘草中异戊烯基黄酮类化合物抗肿瘤活性构效关系初步研究（英文）作者机构：北京大学医学部药学院化学生物学系北京100191 北京大学医学部药学院天然药物学系北京100191
出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)
年 卷 期：2016年第25卷第1期
页 面：23-29页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：National Natural Science Foundation of China(Grant No.81472657 and 81272468)
主 题：Prenylated flavonoids Licorice Anti-cancer Structure-activity relationship
摘 要：Prenylated flavonoids are mainly distributed in Leguminosae and Moraceae plants, and they have been reported to possess various biological activities. Previously, we have reported a prenylated isoflavonoid, isoangustone A（IAA） from licorice（Glycyrrhiza uralensis）, which induces apoptosis in colorectal cancer cells by disrupting mitochondrial functions. In the present study, we compared a group of flavonoids from licorice with IAA for their anti-proliferation activities and effects on intracellular signaling. The results indicated that the isoprenyl groups on the A and B rings, the hydroxyl groups at the ortho position of isoprenyl on A ring and the conjugated plane of C ring might contribute to the anti-cancer activity of prenylated flavonoids. Based on the above structure-activity relationship, we further identified four prenylated flavonoids with similar anti-cancer activities from licorice. Taken together, our present study established a preliminary structure-activity relationship of anti-cancer prenylated flavonoids, and our data provided important leading compounds from licorice, which deserved further research and development.
维普期刊数据库
同方期刊数据库