Development in mechanisms of ischemic mitral regurgitation

作     者：HUANG Wei-lin FU Qiang 

作者机构：Department of Cardiology Zhujiang Hospital Southern Medical University Guangzhou Guangdong 510280 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第9期

页      面：1766-1770页

核心收录：

学科分类：0710[理学-生物学] 12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 07[理学] 08[工学] 071002[理学-动物学] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：myocardial ischemia mitral regurgitation mitral valve insufficiency 

摘      要：Objective The clinical diagnosis and treatment of ischemia mitral regurgitation （IMR） remained difficult because of its unclear mechanisms. This paper reviews studies on the mechanisms of IMR during the last 20 years, and discusses the relevance of the various mechanisms. Data sources Data used in this review were mainly from CNKI and Pubmed in English. The search terms were ＂ischemia mitral regurgitation mechanism＂, ＂myocardial infarction＂ AND ＂mitral regurgitation＂. Study selection Articles were selected if they involved mechanisms of IMR. Results IMR is one of the common complications of coronary artery disease. But currently, the clinical diagnosis and treatment of IMR remained difficult because of its unclear mechanisms. Conclusions For now, dominating theory of ischemic mitral regurgitation mechanisms are left ventricular remodeling, imbalance of leaflet tethering and the closing force, left ventricular dysfunction, changes in spatial structure of the annulus and the dyssynchrony of the left ventricular electromechanical activity.