aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza

作     者：Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen 

作者机构：Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100193 China Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China Guangzhou Pharmaceutical Holding Limited Guangzhou 510140 China Institute of Chinese Medical Sciences University of Macao Macao 999078 China Queensland Alliance for Agriculture and Food Innovation The University of Queensland Brisbane 4072 Australia Department of Microbiology Immunology and Biochemistry University of Tennessee Health Science Center Memphis TN 38163 USA Wellcome Trust Sanger Institute. Hinxton C.B10 1SA UK Roy J. Carver Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA.50011 USA These authors have contributed equally to this article. 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2016年第9卷第6期

页      面：949-952页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 10[医学] 

基　　金：国家自然科学基金 the National Key Technology R&D Program 国家973计划 the US National Institutes of Health 

主　　题：Lamiaceae traditional tanshinones 

摘      要：Dear Editor Salvia miltiorrhiza Bunge （Danshen） is a medicinal plant of the Lamiaceae family, and its dried roots have long been used in traditional Chinese medicine with hydrophilic phenolic acids and tanshinones as pharmaceutically active components （Zhang et al., 2014; Xu et al., 2016）. The first step of tanshinone biosynthesis is bicyclization of the general diterpene precursor （E,E,E）-geranylgeranyl diphosphate （GGPP） to copalyl diphosphate （CPP） by CPP synthases （CPSs）, which is followed by a cyclization or rearrangement reaction catalyzed by kaurene synthase-like enzymes （KSL）. The resulting intermediate is usually an olefin, which requires the insertion of oxygen by cytochrome P450 mono-oxygenases （CYPs） for the final production of diterpenoids （Zi et al., 2014）. While the CPS, KSL, and several early acting CYPs （CYP76AH1, CYP76AH3, and CYP76AK1） for tanshinone biosynthesis have been identified in S. miltiorrhiza （Gao et al., 2009; Guo et al., 2013, 2016; Zi and Peters, 2013）, the majority of the overall biosynthetic pathway, as well as the relevant regulatory factors associated with tanshinone production, remains elusive （Figure 1B）.