Phosphine-catalyzed [4＋2] Annulations of α-Aminonitriles with Allenoates： Synthesis of Functionalized Tetrahydropyridines
Phosphine-catalyzed [4＋2] Annulations of α-Aminonitriles with Allenoates： Synthesis of Functionalized Tetrahydropyridines作者机构：Department of Organic Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China Department of Chemistry Kim Ⅱ Sung University Pyongyang D. P. R. Korea
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2016年第32卷第3期
页 面：385-389页
核心收录：
学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：Supported by the National Natural Science Foundation of China(No. 21372096)
主 题：Annulation Catalysis Tetrahydropyridine
摘 要：Phosphine-catalyzed [4＋2] annulations of 2-（acetoxymethyl）buta-2,3-dienoates with α-aminonitriles have been developed, in which a-aminonitriles serve as C, N-bisnucleophilic reaction partners and 2-（acetoxymethyl）buta- 2,3-dienoates as ＂C4 synthons＂ respectively. A number of a-aminonitriles could be successfully applied to giving multifunctional desired products using PPh3 as catalyst. This method provides a facile entry to access polysubstituted tetrahydropyridines bearing quaternary carbon centers. The possible reaction mechanism was also proposed.
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