Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine

作     者：Die Cheng Deng Ke Liu Mo Liu Ying Liu Wei Ren Xu Chang Xiao Liu 

作者机构：Department of Pharmaceutical Engineering School of Chemical Engineering and Technology Iianjin University llanjin 300072 People＇s Republic of China Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research Tianjin 300193 People＇s Republic of China State Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Tianjin 300193 People＇s Republic of China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第6期

页      面：1075-1079页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 09[农学] 0904[农学-植物保护] 0703[理学-化学] 

主　　题：Thienopyridines Anti-platelet aggregation activities P2Y12 receptors 3D-QSAR 

摘      要：A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine were synthesized and structurally characterized by 1H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design.