ACUPUNCTURE EFFECT ON MOTOR FUNCTIONAL CONNECTIVITY CHANGE IN FACIAL PALSY:AN fMRI STUDY

作     者：Abdalla Zein E. Jeungchan Lee Seulgi Eun Yifang Zhu Yuanyuan Wu Chuanfu Li Jun Yang Kyungmo Park 

作者机构：Department of Biomedical EngineeringKyung Hee University Laboratory of Digital Medical ImagingFirst Affiliated Hospital of Anhui University of Chinese Medicine 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报(英文))

年 卷 期：2014年第3期

页      面：220-220页

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

主　　题：fMRI ACUPUNCTURE EFFECT ON MOTOR FUNCTIONAL CONNECTIVITY CHANGE IN FACIAL PALSY ROI 

摘      要：Background: Bell’s palsy(BP) is common peripheral idiopathic disease that affects the facial nerve(CN VII) and causes an inability to control facial muscles on the affected side and it was known to be treated by *** investigated acupuncture effects on the resting state brain connectivity due to neuroplasticity in patients with *** hypothesized that BP and acupuncture modulates motor cortex regions connectivity with other brain regions during resting ***: According to disease duration and House-Brackmann score(grade the degree of nerve damage in BP), we enrolled59 BP patients(treated by acupuncture in Hegu(LI4)) in three groups: early(within two weeks after onset), later(after two weeks before recovery) and healed(after recovery).Some patients participated multiple times in different *** had35 healthy(normal) volunteers as control *** fMRI scans(pre- and post-acupuncture) using 1.5T MR scanner(Siemens Symphony, Siemens Medical, Erlanger, Germany)were applied(10 minutes resting state with 3 second TR).We used seed voxel analysis approach for investigating functional connectivity of M1 regions of mouth and forehead with other brain regions from normal to healed *** took 4 regionsof interest(ROI), 2 right and 2 left based on our previous motor task ***: There were differences between later and healed in left S2, left superior and middle temporal gyrus with right forehead ROI and DLPFC and middle cingulate gyrus for left mouth *** there were differences between normal and healed in left supramarginal gyrus, left S1 and M1 facial regions, left and right cuneus, and left and right lingual ***: We found functional neuroplasticity changes of brain regions connectivity with our ROIs due to the BP and *** resulted regions are related to sensorymotor regions, motor association regions, attention and motor learning.