Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women

作     者：Yusi Chen Qi Guo Min Zhang Shumin Song Tonggui Quan Tiepeng Zhao Hongliang Li Lijuan Guo Tiejian Jiang Guangwei Wang 

作者机构：Institute of Endocrinology and Metabolism The Second Xiangya Hospital of Central South University Changsha China Hunan University of Medicine Huaihua China Department of Endocrinology The Xiangya Hospital of Central South University Changsha China 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2016年第4卷第1期

页      面：55-59页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Grant 81570806 from the National Natural Science Foundation of China 

主　　题：GDF bone Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women BMD 

摘      要：Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density （BMD） were determined in 169 postmenopausal Chinese women （47-78 years old）. GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index （BMI）, the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase （BAP） was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen （NTX） and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.