N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis

作     者：SongQingWANG OmarA.IBRAHIMI PanLI KangZHAO 

作者机构：CollegeofPharmaceuticalsandBiotechnologyTianjinUniversityTianjin300072 DepartmentofChemistryNewYorkUniversityNewYorkNY10003USA 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2004年第15卷第1期

页      面：1-4页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR000480] Funding Source: NIH RePORTER NCRR NIH HHS [P41 RR000480-28S10106] Funding Source: Medline 

主　　题：SN' reaction pyrrolidines oxime hydroxylamine. 

摘      要：Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2 mechanism to give the desired N-alkoxyl pyrrolidines.