Radiation Effects on the Immunological Functions and Membranes of Alveolar Macrophages of Rats

作     者：GONG YIFEN, Hu LIANPING AND Wu DECHANGInstitute of Radiation Medicine, Beijing, China 

作者机构：Institute of Radiation Medicine Beijing China. 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1991年第4卷第4期

页      面：348-358页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100402[医学-劳动卫生与环境卫生学] 10[医学] 

主　　题：Radiation Effects on the Immunological Functions and Membranes of Alveolar Macrophages of Rats 

摘      要：Alveolar macrophages (AM) from BCG activated Wistar rat were irradiated with different doses of Gamma rays in vitro. The effects of radiation on their immunological functions and membrane damage were studied. The non-specific cytotoxicity and specific phagocytosis of AM irradiated with dose of 0, 100, 300 and 500 Gy decreased with the increase in dose. The relative fractions of Lactate Dehydrogenase and Beta-glucuronidase (β-glu) activity in supernatant increased with the increase in dose. There was a correlation between the suppression of immunological functions and the degree of damage of cytoplasmic and lysosomal membranes of AM after irradiation. Na2SeO3, a protective agent of cell membranes, alleviated this effect on the suppressive cytotoxicity indices of irradiated AM.