Probing hydroxyl radical generation from H2O2 upon plasmon excitation of gold nanorods using electron spin resonance： Molecular oxygen-mediated activation

作     者：Tao wen Hui Zhang Yu Chong Wayne G. Wamer Jun-Jie Yin Xiaochun Wu 

作者机构：ing I O0190 China Division of Analytical Chemistry Office of Regulatory Science Center for Food Safety and Applied Nutrition US Food and Drug Administration College Park MD 20740 USA Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100005 China Division of Bioanalytical Chemistry Office of Regulatory Science Center for Food Safety and Applied Nutrition US Food and Drug Administration College Park MD 20740 USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2016年第9卷第6期

页      面：1663-1673页

核心收录：

学科分类：081702[工学-化学工艺] 080202[工学-机械电子工程] 08[工学] 0817[工学-化学工程与技术] 0802[工学-机械工程] 

基　　金：国家973计划 国家自然科学基金 supported by a regulatory science grant under the FDA Nanotechnology CORES Program The authors appreciate Dr. Lili Fox Velez (Office of Regulatory Science, CFSAN) for providing scientific writing support support or endorsement by the U.S. FDA is intended or should be inferred 

主　　题：gold nanorod oxygen activation hydroxyl radicalplasmon catalysis electron spin resonance 

摘      要：Gold nanostructures are among the noble metal nanomaterials being intensely studied due to their good biocompatibility, tunable localized surface plasmon resonance （SPR）, and ease of modification. These properties give gold nano- structures many potential chemical and biomedical applications. Herein, we demonstrate the critical role of oxygen activation during the decomposition of hydrogen peroxide （H202） in the presence of photoexcited gold nanorods （AuNRs） by using electron spin resonance （ESR） techniques. Upon SPR excitation, 02 is activated first, and the resulting reactive intermediates further activate H202 to produce ,OH. The reactive intermediates exhibit singlet oxygen-like （102-1ike） reactivity, indicated by 102-specific oxidation reaction, quenching behaviors, and the lack of the typical 102 ESR signal. In addition, by using the antioxidant sodium ascorbate （NaA） as an example, we show that hydroxyl radicals from H202 activation can induce much stronger NaA oxidation than that in the absence of H202. These results may have significant biomedical implications. For example, as oxidative stress levels are known to influence tumorigenesis and cancer progression, the ability to control redox status inside tumor microenvironments using noble metal nanostructures may provide new strategies for regulating the metabolism of reactive oxygen species and new approaches for cancer treatment.