Facilitating transparency in spinal cord injury studies using data standards and ontologies

作     者：Vance P.Lemmon Saminda Abeyruwan Ubbo Visser John L.Bixby 

作者机构：Department of Neurological SurgeryUniversity of Miami Miami Project to Cure ParalysisUniversity of Miami Center for Computational ScienceUniversity of Miami Department of Computer ScienceUniversity of Miami Molecular&Cellular PharmacologyUniversity of Miami 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第1期

页      面：6-7页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Research in the Lemmon/Bixby lab is supported by NIH grants NS080145 and NS059866 by the Miami Project to Cure Paralysis 

主　　题：data Facilitating transparency in spinal cord injury studies using data standards and ontologies SCI 

摘      要：Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both the intrinsic factors and the environmental factors that regulate axon growth, but this large body of information has not yet resulted in clinically available thera- peutics. This therapeutic bottleneck has many root causes, but a consensus is emerging that one contributing factor is a lack of standards for experi- mental design and reporting. The absence of reporting standards, and even of commonly accepted definitions of key words, also make data mining and bioinformatics analysis of neural plasticity and regeneration difficult, if not impossible. This short review will consider relevant background and poten- tial solutions to this problem in the axon regeneration domain.