Evaluation of the Prostate Imaging Reporting and Data System for Magnetic Resonance Imaging Diagnosis of Prostate Cancer in Patients with Prostate-specific Antigen 〈20 ng/ml

作     者：Xuan Wang Jian-Ye Wang Chun-Mei Li Ya-Qun Zhang Jian-Long Wang Ben Wan Wei Zhang Min Chen Sa-Ying Li Gang Wan Ming Liu 

作者机构：Department of Urology Beijing Hospital Beijing 100730 China Department of Radiology Beijing Hospital Beijing 100730 China Department of Pathology Beijing Hospital Beijing 100730 China Department of Medical Statistics Beijing Ditan Hospital Beijing 100015 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2016年第129卷第12期

页      面：1432-1438页

核心收录：

学科分类：090603[农学-临床兽医学] 12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 1002[医学-临床医学] 09[农学] 0906[农学-兽医学] 

基　　金：supported by a grant from Beijing Municipal Science and Technology Commission 

主　　题：Diagnosis Magnetic Resonance Imaging Prostate Cancer Prostate Imaging Reporting and Data System 

摘      要：Background： The European Society of Urogenital Radiology has built the Prostate Imaging Reporting and Data System （PI-RADS） for standardizing the diagnosis of prostate cancer （PCa）. This study evaluated the PI-RADS diagnosis method in patients with prostate-specific antigen （PSA） 〈20 ng/ml. Methods： A total of 133 patients with PSA 〈20 ng/ml were prospectively recruited. T2-weighted （T2WI） and diffusion-weighted （DWI） magnetic resonance images of the prostate were acquired before a 12-core transrectal prostate biopsy. Each patient＇s peripheral zone was divided into six regions on the images; each region corresponded to two of the 12 biopsy cores. T2WI, DWI, and T2W1 ＋ DWI scores were computed according to PI-RADS. The diagnostic accuracy of the PI-RADS score was evaluated using histopathology of prostate biopsies as the reference standard. Results： PCa was histologically diagnosed in 169 （21.2%） regions. Increased PI-RADS score correlated positively with increased cancer detection rate. The cancer detection rate for scores 1 to 5 was 2.8%, 15.0%, 34.6%, 52.6%, and 88.9%, respectively, using T2W1 and 12.0%, 20.2%, 48.0%, 85.7%, and 93.3%, respectively, using DWI. For T2WI ＋ DWI, the cancer detection rate was 1.5% （score 2）, 13.5% （scores 3-4）, 41.3% （scores 5-6）, 75.9% （scores 7-8）, and 92.3% （scores 9-10）. The area under the curve for cancer detection was 0.700 （T2WI）, 0.735 （DWI） and 0.749 （T2WI ＋ DWI）. The sensitivity and specificity were 53.8% and 89.2%, respectively, when The summed score ofT2Wl ＋ DWI